Vascular disease: Trialling stem cell treatment for vascular disease

Nature Reviews Nephrology 13, 384 (2017). doi:10.1038/nrneph.2017.76 Author: Katharine H. Wrighton In a study of mesenchymal stem cells (MSCs) to treat atherosclerotic renovascular disease, 28 patients received standard medical treatment, 14 of whom also received a single infusion of MSCs. Patients who received MSCs showed no adverse clinical effects. 3 months after treatment, cortical perfusion and
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research

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CONCLUSIONS: ASC sheets prevented cardiac dysfunctions and remodeling after MI in a rat model via VEGF secretion. Inhibition of VEGF effects by carvedilol abolished their beneficial effects. PMID: 31527337 [PubMed - as supplied by publisher]
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
Publication date: Available online 7 September 2019Source: Journal of Bioscience and BioengineeringAuthor(s): Angela De Luca, Ilenia Vitrano, Viviana Costa, Lavinia Raimondi, Valeria Carina, Daniele Bellavia, Gioacchino Conoscenti, Rossella Di Falco, Francesco Carfì Pavia, Vincenzo La Carrubba, Valerio Brucato, Gianluca GiavaresiTissue engineering offers new approaches to repair bone defects, which cannot be repaired physiologically, developing scaffolds that mimic bone tissue architecture. Furthermore, biomechanical stimulation induced by bioreactor, provides biomechanical cues that regulate a wide range of cellula...
Source: Journal of Bioscience and Bioengineering - Category: Biomedical Science Source Type: research
Authors: Bernasconi P, Borsani O Abstract One of the most urgent needs in AML is to improve the disease cure rate as relapse still occurs in 60-80% of patients. Recent evidence suggests that dismal clinical outcomes may be improved by a better definition of the tight interaction between the AML cell population and the bone marrow (BM) microenvironment ("the niche"); the latter has been progressively highlighted to have an active role in the disease process. It has now been well established that the leukemic population may misinterpret niche-derived signals and remodel the niche, providing a shelter to AML...
Source: Journal of Oncology - Category: Cancer & Oncology Tags: J Oncol Source Type: research
Purpose of review It has been increasingly common to use adipose tissue for regenerative and reconstructive purposes. Applications of autologous fat transfer and different stem cell therapies have significant limitations and adipose tissue engineering may have the potential to be an important strategy in the reconstruction of large tissue defects. A better understanding of adipogenesis will help to develop strategies to make adipose tissue more effective for repairing volumetric defects. Recent findings We provide an overview of the current applications of adipose tissue transfer and cellular therapy methods for soft ...
Source: Current Opinion in Organ Transplantation - Category: Surgery Tags: ORGANOGENESIS: Edited by Giuseppe Orlando Source Type: research
In this study, we present the retina-on-a-chip (RoC), a novel microphysiological model of the human retina integrating more than seven different essential retinal cell-types derived from hiPSCs. It provides vasculature-like perfusion and enables, for the first time, the recapitulation of the interaction of mature photoreceptor segments with RPE in vitro. We show that this interaction enhances the formation of outer segment-like structures and the establishment of in vivo-like physiological processes such as outer segment phagocytosis and calcium dynamics. In addition, we demonstrate the applicability of the RoC for drug te...
Source: eLife - Category: Biomedical Science Tags: Human Biology and Medicine Stem Cells and Regenerative Medicine Source Type: research
Abstract Ischemic heart diseases like myocardial infarction are the largest contributors to cardiovascular disease world-wide. The resulting cardiac cell death impairs function of the heart and can lead to heart failure and death. Reperfusion of the ischemic tissue is necessary but causes damage to the surrounding tissue by re-perfusion injury. Cortical bone stem cells (CBSCs) have been shown to increase pump function and decrease scar size in a large animal swine model of myocardial infarction (MI). To investigate the potential mechanism for these changes, we hypothesized that CBSCs were altering cardiac cell dea...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
Background: Stem cell therapy of acute myocardial infarction is proving to be a promising approach to repair the injured myocardia. However, the time window for stem cell transplantation is important and yet difficult to determine since it produces much different therapeutic effect at different times after myocardial infarction. Stromal cell-derived factor-1 (SDF-1) plays a pivotal role in the mobilization, homing, proliferation and differentiation of transplanted stem cells. Here, by using of ultrasound molecular imaging via targeted microbubbles, we determined the dynamic expression of SDF-1 in a swine model of acute myo...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: In conclusion, this vascular graft may hold the potential to regenerate functional small diameter vessels for cardiovascular tissue repair. PMID: 31379220 [PubMed - as supplied by publisher]
Source: Connective Tissue Research - Category: Research Tags: Connect Tissue Res Source Type: research
Abstract PURPOSE OF REVIEW: It has been increasingly common to use adipose tissue for regenerative and reconstructive purposes. Applications of autologous fat transfer and different stem cell therapies have significant limitations and adipose tissue engineering may have the potential to be an important strategy in the reconstruction of large tissue defects. A better understanding of adipogenesis will help to develop strategies to make adipose tissue more effective for repairing volumetric defects. RECENT FINDINGS: We provide an overview of the current applications of adipose tissue transfer and cellular thera...
Source: Current Opinion in Organ Transplantation - Category: Transplant Surgery Authors: Tags: Curr Opin Organ Transplant Source Type: research
Publication date: Available online 29 July 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Konstantinos Theodoridis, Eleni Aggelidou, Marilena Manthou, Efterpi Demiri, Athina Bakopoulou, Aristeidis KritisAbstractEfforts on bioengineering are directed towards the construction of biocompatible scaffolds and the determination of the most favorable microenvironment, which will better support cell proliferation and differentiation. Perfusion bioreactors are attracting growing attention as an effective, modern tool in tissue engineering. A natural biomaterial extensively used in regenerative medicine with outstandin...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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