Lupus nephritis: Cholesterol accumulation in DCs promotes autoimmunity

Nature Reviews Nephrology 13, 383 (2017). doi:10.1038/nrneph.2017.72 Author: Ellen F. Carney Cholesterol accumulation in dendritic cells (DCs) activates inflammatory signalling pathways that promote autoimmunity. This new finding from Marit Westerterp and colleagues suggests that suppression of DC cholesterol efflux pathways might have a role in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE).
Source: Nature Reviews Nephrology - Category: Urology & Nephrology Authors: Tags: Research Highlight Source Type: research