G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon

Plasmodium vivax parasites are the predominant cause of malaria infections in the Brazilian Amazon. Infected individuals are treated with primaquine, which can induce haemolytic anaemi...
Source: Malaria Journal - Category: Infectious Diseases Authors: Source Type: research

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Green Chem., 2019, Accepted Manuscript DOI: 10.1039/C9GC02478F, PaperV ânia Mendes do Prado, Thiago Branquinho Queiroz, Paula M Sa, Rafael Cardoso Seiceira, Nubia Boechat, Fabio Furlan Ferreira Mechanochemistry refers to a chemical reaction induced by mechanical energy involving solids. This method provides several advantages over solution-phase synthesis, such as minimizing the need for large volumes of solvents... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Green Chem. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01631G, PaperEmerson A Fonseca, Lucas Lafet á, Renan Cunha, Hudson Miranda, João Campos, Helton Medeiros, Marco Aurelio Romano-Silva, Raigna Silva, Alexandre Barbosa, Rafael Vieira, L Malard, Ado Jorio Global prevalence of Alzheimer ’s disease (AD) points to endemic levels, especially considering the increase on average life expectancy worldwide. AD diagnosis based on early biomarkers, in addition to a better... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
This week's case was donated by Blaine Mathison and Marc Couturier. The following forms were seen on peripheral blood smears. No travel history is available at this time. How would you recommend reporting out this case? Are there any additional studies you would recommend?
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
[Cameroon Tribune] Cameroon's imprint in fighting HIV AIDS, TB and malaria is found in its encompassing programme epitomised by the action of the First Lady, Chantal Biya.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Conclusion: The result of this study supports the hypothesis that inheriting the G6PD deficiency gene and sickle cell gene (both in homozygous and heterozygous form) reduces the severity of malaria parasite infection and hence protects against severe acute malaria while having less effect on infection.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
The objective would be a drug with> 95% efficacy and that is easily tolerated, including in children and pregnant women. For individuals who prefer weekly rather than daily drug administration, a further objective is a product that is administered weekly. The deficiencies of present agents are parasite resistance to chloroquine, neuropsychiatric liability of mefloquine, the need for daily dosing for atovaquone-proguanil, and daily dosing plus adverse reactions for doxycycline. A primaquine analogue, tafenoquine has a 17-day half-life and was approved for weekly prophylaxis in the United States and in Australia in 2018. ...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 007 When you think tropical medicine, malaria has to be near the top. It can be fairly complex and fortunately treatment has become a lot simpler. This post is designed to walk you through the basic principals with links to more in depth teaching if your niche is travel medicine, laboratory diagnostics or management of severe or cerebral malaria. If you stubbled on this post while drinking a cup of tea or sitting on the throne and want a fe...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine malaria Plasmodium plasmodium falciparum plasmodium knowles plasmodium malariae plasmodium ovale plasmodium vivax Source Type: blogs
We described a time series of malaria incidence for the 72 months of study for the entire area and divided by state. To address irregularities and error components, we smoothed the time series using a centred moving average of k=5, in which k is the number of observations that are averaged. This value was selected because it highlighted the best pattern of the data. We used the method of seasonal decomposition by Loess smoothing to capture the trend, seasonal and irregular components. A generalized linear model was applied to quantify this overall trend, and the Kruskal-Wallis Rank Sum test was applied to test for seasonal...
Source: PLOS Currents Outbreaks - Category: Epidemiology Authors: Source Type: research
This study was undertaken to investigate the abilities of various polymorphic erythrocytes to support in vitro growth of Plasmodium falciparum parasites. Methods: In this study under in vitro condition the ability of P. falciparum parasites to grow was assessed in the erythrocytes obtained from a total of 40 patients with various haemoglobinopathies, such as β-thalassaemia (β-Thal), sickle cell anaemia, erythroenzymopathy-like glucose-6-phosphate dehydrogenase deficiency and membranopathy-like hereditary spherocytosis. Results: Significantly reduced in vitro invasion and growth of parasites was seen in ...
Source: Indian J Med Res - Category: Research Authors: Tags: Indian J Med Res Source Type: research
This study aimed to evaluate the prevalence and alteration of hematological parameters in malaria patients with a glucose-6-phosphate dehydrogenase (G6PD) deficiency, in the western region of Thailand, an endemic region for malaria. Methods Data about patients with malaria hospitalized between 2013 and 2015 were collected. Clinical and sociodemographic characteristics such as age and gender, diagnosis on admission, and parasitological results were mined from medical records of the laboratory unit of the Phop Phra Hospital in Tak Province, Thailand. Venous blood samples were colle...
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
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