[Correspondence] Metabolic mediators of body-mass index and cardiovascular risk

The Global Burden of Metabolic Risk Factors for Chronic Diseases Collaboration reported that nearly half of the excess risk of body-mass index (BMI) on coronary heart disease and three-quarters of that on stroke is mediated through blood pressure, cholesterol, and markers of glycaemia. Although these findings correctly support the idea that the adverse effects of high BMI can be substantially mitigated by targeting its metabolic mediators, the report's results underestimate by about 25% the extent to which these metabolic factors mediate the effects of BMI on cardiovascular risk.

Source: LANCET - June 13, 2014 Category: Journals (General) Authors: David Wormser, Angela M Wood, Emanuele Di Angelantonio, Simon G Thompson, John Danesh, for the Emerging Risk Factors Collaboration Tags: Correspondence Source Type: research