Hepatocellular Carcinoma: a Comprehensive Review of Biomarkers, Clinical Aspects, and Therapy
Hepatocellular Carcinoma: a Comprehensive Review of
Biomarkers, Clinical Aspects, and Therapy
Asian Pac J Cancer Prev. 2017 04 01;18(4):863-872
Authors: Tunissiolli NM, Castanhole-Nunes, Biselli-Chicote PR, Pavarino, da Silva RF, da Silva RD, Goloni-Bertollo EM
Abstract
Hepatocellular carcinoma (HCC) is a cause of several deaths related to cancer worldwidely. In early stage, curative
treatments such as surgical resection, liver transplant and local ablation can improve the patient ´s survival. However,
the disease is detected in advanced stage; moreover some available therapies are restricted to palliative care and local
treatment. Early detections of HCC and adequate therapy are crucial to increase survival as well as to improve the
patient´s quality of life. Therefore, researchers have been investigating molecular biomarkers with high sensibility and
reliability as Golgi 73 protein (GP73), Glypican-3 (GPC3), Osteopontin (OPN), microRNAs and others. MicroRNAs
can regulate important pathways on carcinogenesis, as tumor angiogenesis and progression. So, they can be considered
as possible markers of prognosis in HCC, and therapeutic target for this tumor type. In this review, we discuss the
recent advances related to the cause (highlighting the main risk factors), treatment, biomarkers, clinic aspects, and
outcome in hepatocellular carcinoma.
PMID: 28545181 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
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