Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1

ConclusionsThis study focuses on recent progress on the role of VCAM-1, an important glycoprotein belonging  to the immunoglobulin (Ig) superfamily of cell surface adhesion molecules in breast cancer angiogenesis, survival and metastasis. Targeting VCAM-1, expressed on the surface of breast cancer cells, and/or its specific ligand VLA-4/α4β1 integrin, expressed on cells at the site of metastasis, may b e a useful strategy to reduce breast cancer cell invasion and metastasis. Various approaches to therapeutically target VCAM-1 and VLA-4 are also discussed.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research