Palmitate-Induced Vacuolar-Type H+-ATPase Inhibition Feeds Forward Into Insulin Resistance and Contractile Dysfunction

In conclusion, lipid oversupply increases CD36-mediated lipid uptake that directly impairs v-ATPase function. This feeds forward to enhanced CD36 translocation and further increased lipid uptake. In the case of palmitate, its accelerated uptake ultimately precipitates into cardiac insulin resistance and contractile dysfunction.

Source: Diabetes - May 22, 2017 Category: Endocrinology Authors: Liu, Y.; Steinbusch, L. K. M.; Nabben, M.; Kapsokalyvas, D.; van Zandvoort, M.; Schönleitner, P.; Antoons, G.; Simons, P. J.; Coumans, W. A.; Geomini, A.; Chanda, D.; Glatz, J. F. C.; Neumann, D.; Luiken, J. J. F. P. Tags: Metabolism Source Type: research