Cellulose Acetate/Poly Lactic Acid Coaxial Wet-Electrospun Scaffold Containing Citalopram-Loaded Gelatin Nanocarriers for Neural Tissue Engineering Applications.

Cellulose Acetate/Poly Lactic Acid Coaxial Wet-Electrospun Scaffold Containing Citalopram-Loaded Gelatin Nanocarriers for Neural Tissue Engineering Applications. Int J Biol Macromol. 2017 May 15;: Authors: Naseri-Nosar M, Salehi M, Hojjati-Emami S Abstract The current study aimed to develop a biodegradable three-dimensional drug-loaded scaffold with the core-shell structured fibrils using coaxial wet-electrospinning for neural tissue engineering application. Poly lactic acid was wet-electrospun as the core, whereas cellulose acetate was fabricated into the fibril's shell. The scaffold then was coated with citalopram-loaded gelatin nanocarriers (CGNs) produced by nanoprecipitation. Scanning electron microscope observation revealed that the fibrils formed a nonwoven structure with the average diameter of ∼950nm. The particle size measurement by a dynamic light scattering device showed an average diameter of ∼200nm. The porosity measurement via the liquid displacement method showed that the scaffold could not meet the accepted ideal porosity percentage of above 80%, and the measured porosity percentage was ∼60%. The contact angle measurement displayed that the CGNs coating made the scaffold highly hydrophilic with a zero degree contact angle. In vitro degradation study in the phosphate buffered saline revealed that the weight of uncoated scaffold remained relatively constant. However, the CGNs-coated scaffold showed ∼45% weight-...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research