Large variability of the activity and chronicity indexes within and between histological classes of lupus nephritis.

Large variability of the activity and chronicity indexes within and between histological classes of lupus nephritis. Rom J Morphol Embryol. 2017;58(1):73-78 Authors: Azoicăi T, Belibou IM, Lozneanu L, Giuşcă SE, Cojocaru E, Căruntu ID Abstract Systemic lupus erythematosus (SLE) is characterized by a multifaceted pathogenesis and a heterogeneous clinical expression. The kidney involvement is almost unavoidable in all forms of SLE with chronic evolution, 75% of patients developing renal lesions defined as lupus nephritis (LN) - a glomerulonephritis with an extremely diverse lesion spectrum. The present study aimed to reevaluate a series of cases diagnosed as LN, focusing on the histological features in correlation with the level of activity and chronicity. The study group comprised 46 patients. The specimens obtained through percutaneous needle biopsies were processed for light microscopy and immunofluorescence exams. The reevaluation process focused on the major morphological parameters ensuring: (i) a detailed description of the lesions, (ii) the class diagnosis in accordance with the International Society of Nephrology÷Renal Pathology Society (ISN÷RPS) classification, (iii) the activity and chronicity indexes. In 39 out of the total of 46 (84.78%) cases, the class of LN established at the time of the renal biopsy was confirmed in the reevaluation process. The differences in diagnosis were present in seven cases, initially cons...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research