Histological Subtypes of Hepatocellular Carcinoma Are Related To Gene Mutations and Molecular Tumour Classification

Malignant primary liver tumours are the second leading cause of cancer-related death worldwide, with an increasing incidence in almost all countries [1]. They are mainly represented by hepatocellular carcinoma (HCC) that results from the malignant transformation of hepatocytes. The most frequent risk factors of HCC comprise alcohol intake, infection by hepatitis B (HBV) or hepatitis C (HCV) viruses, and metabolic syndrome [2]. Although surveillance protocols of patients at-risk to develop HCC have significantly improved, clinical outcome remains poor with a majority of patients presenting with advanced disease not eligible for curative therapy [3].

Source: Journal of Hepatology - May 19, 2017 Category: Gastroenterology Authors: Julien Calderaro, Gabrielle Couchy, Sandrine Imbeaud, Giuliana Amaddeo, Eric Letouz é, Jean-Frédéric Blanc, Christophe Laurent, Yacine Hajji, Daniel Azoulay, Paulette Bioulac-Sage, Jean-Charles Nault, Jessica Zucman-Rossi Source Type: research