Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review.
Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review. Acta Derm Venereol. 2017 May 17;: Authors: Eskeland S, Halvorsen JA, Tanum L Abstract There is increasing evidence of clinically relevant anti-inflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association with 5 common inflammatory skin disorders: chronic urticaria, psoriasis, atopic dermatitis, other eczema, and alopecia areata. From January 1984 to June 2016, publications included a total of 1,252 dermatological patients in 28 trials or case reports. These unambiguously reported a reduced burden of dermatological symptoms in relation to treatment with antidepressants. Several randomized controlled trials of first-generation antidepressants have been published, while studies of modern antidepressants are usually open-label, yet more informative, regarding patients' characteristics and study procedures. These overall positive findings may indicate a rationale, beyond treating comorbid psychiatric disorders, for the use of antidepressants in dermatology. Further research into modern tolerable antidepressants, including selective serotonin re-uptake inhibitors, mirtazapine and bupropion, is required. PMID: 28512664 [PubMed - as supplied by publisher]
Authors: Dutzan N, Abusleme L Abstract T helper 17 (Th17) cells were first described as a T helper subset involved in the pathogenesis of experimental autoimmune inflammation. Since then, these cells have been described as orchestrators of immunopathology in several human inflammatory conditions including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. More recently, the crucial role of Th17 cells in the regulation of immunity and protection of barrier sites has been unveiled. In the present work, we review the available evidence regarding Th17 cells in health and disease with a focus on the oral m...
CONCLUSIONS: Cutaneous vasculopathy related to the skin, such as livedo reticularis and ulcers of torpid evolution due to cutaneous vasculopathy are extremely rare. Thus, it is necessary to include skin ulcers as one of the phenotypic manifestations of NF-1. PMID: 31730516 [PubMed - in process]
CONCLUSIONS: The authors suggest stasis mucinosis and OALM represent the spectrum of euthyroid mucin depositional disease in varying clinical settings. PMID: 31730515 [PubMed - in process]
CONCLUSIONS: These results suggest resveratrol has therapeutic effects in the treatment of AD. PMID: 31730508 [PubMed - as supplied by publisher]
ConclusionsIn CSU the likelihood of clinical improvement from laboratory testing is very low, and testing not cost-effective. These data support recommendations to not routinely perform laboratory testing in CSU patients with otherwise normal histories and physical evaluations.
ConclusionsCSU has strong negative effects on female sexual function, especially in patients with angioedema. Additional studies on sexual health in patients with CSU are needed and should focus on the impact of effective treatment on sexual functioning.
Publication date: Available online 18 November 2019Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Puja Sood Rajani, Hayley Martin, Marion Groetch, Kirsi M. JärvinenAbstractBreastfeeding is currently recommended as the optimal source of nutrition to infants. However, there are several studies that have shown clinical IgE and non-IgE-mediated reactions to foods in exclusively breastfeeding infants, specifically to cow’s milk, egg, peanut, and fish. Literature suggests that antigenic food proteins present in human milk can be found in substantial enough amounts to elicit clinical reac...
Condition: Psoriasis Interventions: Drug: BMS-986165; Other: Placebo Sponsor: Bristol-Myers Squibb Not yet recruiting
Conditions: Alcohol Use Disorder; Alcoholism; Alcohol Dependence Interventions: Drug: Varenicline Tartrate 1 mg b.i.d; Drug: Bupropion Hydrochloride 150 mg b.i.d; Other: Placebo for varenicline; Other: Palcebo for bupropion Sponsor: Vastra Gotaland Region Recruiting
Authors: Guarneri C, Lotti J, Fioranelli M, Roccia MG, Lotti T, Guarneri F Abstract Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of derm...