Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review.

Antidepressants have Anti-inflammatory Effects that may be Relevant to Dermatology: A Systematic Review. Acta Derm Venereol. 2017 May 17;: Authors: Eskeland S, Halvorsen JA, Tanum L Abstract There is increasing evidence of clinically relevant anti-inflammatory effects of monoaminergic antidepressants. PubMed and Ovid databases were searched systematically for the use and efficacy of antidepressants in association with 5 common inflammatory skin disorders: chronic urticaria, psoriasis, atopic dermatitis, other eczema, and alopecia areata. From January 1984 to June 2016, publications included a total of 1,252 dermatological patients in 28 trials or case reports. These unambiguously reported a reduced burden of dermatological symptoms in relation to treatment with antidepressants. Several randomized controlled trials of first-generation antidepressants have been published, while studies of modern antidepressants are usually open-label, yet more informative, regarding patients' characteristics and study procedures. These overall positive findings may indicate a rationale, beyond treating comorbid psychiatric disorders, for the use of antidepressants in dermatology. Further research into modern tolerable antidepressants, including selective serotonin re-uptake inhibitors, mirtazapine and bupropion, is required. PMID: 28512664 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
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Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
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Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
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Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
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Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Condition:   Psoriasis Interventions:   Drug: BMS-986165;   Other: Placebo Sponsor:   Bristol-Myers Squibb Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Alcohol Use Disorder;   Alcoholism;   Alcohol Dependence Interventions:   Drug: Varenicline Tartrate 1 mg b.i.d;   Drug: Bupropion Hydrochloride 150 mg b.i.d;   Other: Placebo for varenicline;   Other: Palcebo for bupropion Sponsor:   Vastra Gotaland Region Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Guarneri C, Lotti J, Fioranelli M, Roccia MG, Lotti T, Guarneri F Abstract Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. pylori infection were suggested in diseases of derm...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
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