Plasma membrane repair: the adaptable cell life-insurance.

Plasma membrane repair: the adaptable cell life-insurance. Curr Opin Cell Biol. 2017 May 13;47:99-107 Authors: Jimenez AJ, Perez F Abstract The plasma membrane is the most basic element necessary for the cell to exist and be distinguishable from its environment. Regulated mechanisms allow tightly controlled communication between intacellular and extracellular medium allowing the maintenance of a specific biochemical environment, optimized for cellular functions. The anarchic and uncontrolled opening of a hole in the PM induces a change in the concentration of ions and oxidizing agents perturbing homeostasis. Fortunately, the cell possesses mechanisms that are capable of reacting to sudden extracellular medium entry and to block the leakage locally. Here we summarize the known mechanisms of membrane repair and how the size of the wound and the resulting calcium entry activates preferentially one or another mechanism adapted to the magnitude of the injury. PMID: 28511145 [PubMed - as supplied by publisher]
Source: Current Opinion in Cell Biology - Category: Cytology Authors: Tags: Curr Opin Cell Biol Source Type: research