Iron Overload is Associated with Perihematoma Edema Growth following Intracerebral Hemorrhage that May Contribute to in-Hospital Mortality and Long-Term Functional Outcome.

Iron Overload is Associated with Perihematoma Edema Growth following Intracerebral Hemorrhage that May Contribute to in-Hospital Mortality and Long-Term Functional Outcome. Curr Neurovasc Res. 2014 May 30; Authors: Bakhshayesh B, Hosseininezhad M, Nazanin S, Saadat SN, Ansar MM, Ramezani H, Saadat SM Abstract Iron overload may contribute to brain damage that involves delayed brain atrophy, edema, and neuronal cell death as well as unfavorable outcome following ischemic stroke and intracerebral hemorrhage (ICH).This prospective study wasperformed to determine the association of serum ferritin level, an iron storage protein, with perihematoma edema (PHE) growth as well as in-hospital mortality and long-term clinical outcome of patients with ICH.Data was collected prospectively from patients with ICH between February 2011 and April 2012. Demographicand clinical datawere recorded and serum ferritin was measured on admission. Brain CT scan was performed on admission and 72 hours later. Volume of hematoma and PHE was calculated using ABC/2 formula. Functional outcome was assessed using modified Rankin Scale.A total of 63 patients were included in this study, of these 11 (17.5%) patients died during the first 72 hours of admission.There was a significant correlation between PHE growth during first 72 hours of hospitalization andserum ferritin (P<0.001) as well as history ofdiabetes mellitus (P<0.001). PHE growth during the first 72-ho...
Source: Current Neurovascular Research - Category: Neurology Authors: Tags: Curr Neurovasc Res Source Type: research