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Hybrid imaging could benefit colorectal cancer patients

The combination of SPECT/CT and fluorescence imaging could help surgeons differentiate...Read more on AuntMinnie.comRelated Reading: New nanoparticles may improve GI scans PET/CT predicts colon cancer response Immunomedics touts cancer study results
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Authors: Zhang Y, Zhao M, Su J, Lu X, Lv K Abstract A novel model for cascading failures in a directed logic network based on the degree strength at a node was proposed. The definitions of in-degree and out-degree strength of a node were initially reconsidered, and the load at a nonisolated node was proposed as the ratio of in-degree strength to out-degree strength of the node. The cascading failure model based on degree strength was applied to the logic network for three types of cancer including adenocarcinoma of lung, prostate cancer, and colon cancer based on their gene expression profiles. In order to highligh...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
This study evaluates a novel technique of laparoscopic ovarian transposition performed by Gynecologic Oncologists prior to pelvic radiation for gynecologic cancer. A retrospective review was completed of all patients that underwent laparoscopic ovarian transposition from February 2007 to June 2017 at one tertiary care cancer. The technique involves salpingectomy, followed by retroperitoneal dissection to move the ovaries lateral to the hepatic and splenic flexures of the colon. Normal ovarian function was defined by the absence of vasomotor symptoms, FSH and menstrual history (if menstruating). The radiation dose to the ov...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Conclusions The evaluation of these results has determined optimal quality indices for the units accredited in the treatment of colorectal cancer. Furthermore, it allows us to establish realistic references in our country, thereby providing a better understanding and comparison of outcomes.
Source: Cirugia Espanola - Category: Surgery Source Type: research
Patients with Medicaid or no insurance have lower survival versus those with private coverage
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gastroenterology, Internal Medicine, Oncology, Surgery, Journal, Source Type: news
Condition:   Colorectal Cancer Intervention:   Drug: FOLFOXIRI Sponsor:   Hanoi Medical University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
FRIDAY, April 20, 2018 -- Compared to patients with private insurance, colon cancer survival is lower for patients with no insurance or with Medicaid, according to a study published in the May issue of Diseases of the Colon&Rectum. Dianne...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Conclusion: Our case report underlines the importance of active endoscopic surveillance of the remaining colon and rectum in patients with diverting stomas and inflammatory bowel disease in order to detect stenosis. If endoscopic control is not possible due to obliteration, surgical therapy must be discussed due to the risk of developing cancer.Case Rep Gastroenterol 2018;12:143 –146
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
This study elucidates a molecular mechanism of cross-resistance to diverse inhibitors of nicotinamide phosphoribosyltransferase (NAMPT) with anticancer activity. We generated a variant of the human colon cancer cell line HCT116, HCT116RFK866, which exhibited primary resistance to the potent NAMPT inhibitor FK866, and was approximately 1,000-fold less sensitive to the drug than the parental HCT116. HCT116RFK866 was found to be cross-resistant to diverse NAMPT inhibitors, including CHS-828, GNE-617, and STF-118804. Whole-exon sequencing revealed two point mutations (H191R and K342R) in NAMPT in HCT116RFK866, only one of whic...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
In this study, we constructed a novel herbal formula, SGE, which contains Ginseng Radix alba, Atractylodis Rhizoma alba, and Hoelen, examined its anti-cancer and anti-cachexia efficacies. In in vitro experiments, SGE induced death of CT-26 murine colon carcinoma cells via endoplasmic reticulum stress, and suppressed the production of inflammatory cytokines in Raw 264.7 murine macrophage-like cells. In addition, SGE treatment attenuated CT-26-induced C2C12 skeletal muscle cell atrophy as well as CT-26-induced reduction in lipid accumulation in 3T3-L1 adipocyte. In CT-26 tumor-bearing mice, daily oral administration of 10 an...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Uev1A-Ubc13 promotes colorectal cancer metastasis through regulating CXCL1 expression via NF-кB activation. Oncotarget. 2018 Mar 23;9(22):15952-15967 Authors: Wu Z, Neufeld H, Torlakovic E, Xiao W Abstract Colorectal cancer is the second most common cause of cancer-related death worldwide. Uncontrolled growth and distant metastasis are hallmarks of colorectal cancer. However, the precise etiological factors and the mechanisms are diverse and still largely unclear. The potential proto-oncogene UEV1A encodes a ubiquitin conjugating enzyme variant, which is required for Ubc13-catalyzed K63-linked poly-ub...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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