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Hybrid imaging could benefit colorectal cancer patients

The combination of SPECT/CT and fluorescence imaging could help surgeons differentiate...Read more on AuntMinnie.comRelated Reading: New nanoparticles may improve GI scans PET/CT predicts colon cancer response Immunomedics touts cancer study results
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Conclusion: RTCC showed unique clinicopathologic features and was associated with a poorer prognosis. PMID: 29354603 [PubMed]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Authors: Baek SK PMID: 29354601 [PubMed]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research
Rubinstein–Taybi syndrome (RSTS) is a multiple congenital anomalies syndrome associated with mutations in CREBBP (70%) and EP300 (5–10%). Previous reports have suggested an increased incidence of specific benign and possibly also malignant tumors. We identified all known individuals diagnosed with RSTS in the Netherlands until 2015 (n = 87) and studied the incidence and character of neoplastic tumors in relation to their CREBBP/EP300 alterations. The population–based Dutch RSTS data are compared to similar data of the Dutch general population and to an overview of case reports and series of ...
Source: American Journal of Medical Genetics Part A - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
(Natural News) Broccoli-based yogurt may seem weird, but it could be beneficial for your colon. New research suggested that the combination of yogurt and broccoli could be used to treat or even prevent colon cancer. The study was conducted by a team of researchers at the National University of Singapore. In the study, a harmless...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Accumulated evidence in the last decade implies that regulation of metabolism by p53 represents a reviving mechanism vital to prevent tumorigenesis. To gain a more in‐depth understanding of metabolic regulation by baseline levels of p53, we employed both metabolomics and transcriptomics analysis with human colon cancer cell‐line HCT116 depleted of p53. Metabolomics analyses with UPLC/quadrupole time‐of‐flight mass spectrometry identified 283 significantly changed metabolites including 138 important metabolites. Transcriptomics analysis with microarray revealed 1317 differentially expressed genes. By integrated anal...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Letter Source Type: research
BACKGROUNDOutcomes have improved significantly in multiple myeloma (MM), but racial disparities in health care access and survival exist. A comprehensive analysis exploring MM care and racial disparities is warranted. METHODSPatients with MM from 1991 to 2010 in the Surveillance, Epidemiology, and End Results‐Medicare database were evaluated for racial trends in clinical myeloma‐defining events (MDEs), the receipt of treatment (drugs and stem cell transplantation; [SCT]), the cost of care, and overall survival (OS). RESULTSAmong 35,842 patients, the frequency of all MDEs at diagnosis increased over time; whereas, in re...
Source: Cancer - Category: Cancer & Oncology Authors: Tags: Original Article Source Type: research
(Reuters Health) - People who consume lots of foods linked to chronic inflammation, such as red meat and refined grains, may be more likely to develop colorectal cancer than individuals who tend to avoid these foods, a U.S. study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
AbstractTargeting of the protein degradation pathway, in particular, the ubiquitin-proteasome system, has emerged as an attractive novel cancer chemotherapeutic modality. Although proteasome inhibitors have been most successfully applied in the treatment of hematological malignancies, they also received continuing interest for the treatment of solid tumors. In this review, we summarize the current positioning of proteasome inhibitors in the treatment of common solid malignancies (e.g., lung, colon, pancreas, breast, and head and neck cancer), addressing topics of their mechanism(s) of action, predictive factors and molecul...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
AbstractPurposeWe aimed to evaluate the efficacy and outcomes of radioembolization with Yttrium-90 (Y-90) microspheres in patients with unresectable and chemorefractory colorectal cancer liver metastasis (CRCLM).MethodsThis single-center study included 43 patients (34 male, 9 female) who underwent radioembolization with Y-90 for unresectable, chemorefractory CRCLM between September 2008 and July 2014. Overall survival (OS), liver progression-free survival (LPFS), overall response rate (ORR), local disease control rate (LDCR), and relations of these parameters with patient disease characteristics were evaluated. OS and LPFS...
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
The objective of this study was to characterize the clinicopathological prognostic factors and treatment patterns for small cell carcinoma (SCC) of the colon, a rare disease without standard treatment guidelines.MethodsWe analyzed clinicopathological and treatment variables for 503 cases of histologically proven SCC colon entered into the National Cancer Database (NCDB) between 2004 and 2013. Survival curves were generated using Kaplan-Meier and compared by the log-rank test. Cox proportional hazard regression was used to control for covariates and evaluate the effect of different treatment modalities on overall survival.R...
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
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