Mutant IDH1 and seizures in patients with glioma

Conclusions:
The D2HG product of IDH1mut may increase neuronal activity by mimicking the activity of glutamate on the NMDA receptor, and IDH1mut gliomas are more likely to cause seizures in patients. This has rapid translational implications for the personalized management of tumor-associated epilepsy, as targeted IDH1mut inhibitors may improve antiepileptic therapy in patients with IDH1mut gliomas.

Source: Neurology - May 8, 2017 Category: Neurology Authors: Chen, H., Judkins, J., Thomas, C., Wu, M., Khoury, L., Benjamin, C. G., Pacione, D., Golfinos, J. G., Kumthekar, P., Ghamsari, F., Chen, L., Lein, P., Chetkovich, D. M., Snuderl, M., Horbinski, C. Tags: Primary brain tumor, Paraneoplastic syndrome, All Epilepsy/Seizures ARTICLE Source Type: research