Improving neurorepair in stroke brain through endogenous neurogenesis-enhancing drugs.

Improving neurorepair in stroke brain through endogenous neurogenesis-enhancing drugs.
Cell Transplant. 2017 Apr 26;:
Authors: Wu KJ, Yu S, Lee JY, Hoffer B, Wang Y
Abstract
Stroke induces not only cell death but also neurorepair. De novo neurogenesis has been found in the subventricular zone(SVZ) of adult mammalian brain days after stroke. Most of these newly generated cells die shortly after the insult. Recent studies have shown that pharmacological manipulation can improve the survival of endogenous neuroprogenitor cells and neural regeneration in stroke rats. As these drugs target the endogenous reparative processes which occur days after stroke, they may provide a prolonged window for stroke therapy. Here, we discuss endogenous neurogenesis-enhancing drugs, and review the general status of stroke therapeutics in evaluating the field of pharmacotherapy for stroke.
PMID: 28447573 [PubMed - as supplied by publisher]

Source: Cell Transplantation - April 26, 2017 Category: Cytology Authors: Wu KJ, Yu S, Lee JY, Hoffer B, Wang Y Tags: Cell Transplant Source Type: research