Decreased Ceramide in Charcot Marie Tooth 2F Mediates Mitochondrial Dysfunction (S53.001)

Conclusions:These results suggest that mutant Hsp27 alters sphingolipid metabolism by dysregulating ceramide levels, producing structural and functional changes in mitochondria that lead to neuronal degeneration in CMT2F. By developing an understanding of the mechanism of how altered ceramide generation affects mitochondria and neurodegeneration, we will be able to identify targets in the development of novel treatments to reduce the severity of CMT2F or other neuropathies with similar mechanisms.Disclosure: Dr. Schwartz has nothing to disclose. Dr. Linzer has nothing to disclose. Dr. Schwartz has nothing to disclose. Dr. Obeid has nothing to disclose.
Source: Neurology - Category: Neurology Authors: Tags: General Neurology: Mechanisms and Diagnosis in Overlapping Medical and Neurological Diseases Source Type: research