Leukocyte response in ischemic stroke is regulated by let7i microRNA (S51.005)

Conclusions:Let7i is decreased in circulating leukocytes of patients with acute ischemic stroke. Mechanisms by which let7i regulates inflammatory response post-stroke include targeting CD86, CXCL8 and HMGB1.Study Supported by: The American Heart Association (GCJ) and the National Institutes of Health (NS075035, NS079153, FRS).Disclosure: Dr. Jickling has nothing to disclose. Dr. Ander has nothing to disclose. Dr. Shroff has nothing to disclose. Dr. Stamova has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Sharp has nothing to disclose.

Source: Neurology - April 17, 2017 Category: Neurology Authors: Jickling, G., Ander, B., Shroff, N., Stamova, B., Liu, D., Sharp, F. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research