Localized over expression of FGF9 in the rat motor cortex reproduces the pathological features of grey matter lesions in progressive multiple sclerosis. (P2.364)

Conclusions:Increasing availability of FGF9 in the rat cortex results in demyelinated lesions that recapitulate the major pathological features associated with grey matter lesions in progressive multiple sclerosis. This observation combined with data demonstrating FGF9 expression is increased in patients identifies FGF9-dependent responses as a logical target for therapies designed to reduce accumulation of disability in patients with progressive disease.Study Supported by: Funding for this study was provided by the Hertie Foundation, Multiple Sclerosis Society and the Naomi Bramson Trust.Disclosure: Dr. Wrzos has nothing to disclose. Dr. McElroy has nothing to disclose. Dr. Thuemmler has nothing to disclose. Dr. Sebastian has nothing to disclose. Dr. Junker has nothing to disclose. Dr. Stadelmann-Nessler has nothing to disclose. Dr. Linington has nothing to disclose.

Source: Neurology - April 17, 2017 Category: Neurology Authors: Wrzos, C., McElroy, D., Thuemmler, K., Sebastian, S., Junker, A., Stadelmann-Nessler, C., Linington, C. Tags: Biomarkers and Experimental Studies for Multiple Sclerosis II Source Type: research