Increased Epilepsy Prevalence in Adults with 22q11 Deletion Syndrome (P1.236)

Conclusions:The prevalence of provoked seizures in adults with 22q11.2DS is higher than in the general population. Hypocalcemia continues to be risk factor for adults, but differently from children, adults with 22qDS are more exposed to psychotropic medications and are more vulnerable to seizures caused by them compared to the general population. These patients are also more likely to develop genetic generalized and focal epilepsy, structural epilepsy (due to malformation of cortical development, trauma, stroke). Further prospective studies are warranted to investigate how 22q11.2 microdeletion leads to an overall decreased seizure threshold.Study Supported by: Brain and Behavior Research Foundation (formerly NARSAD)Disclosure: Dr. Wither has nothing to disclose. Dr. MacDonald has nothing to disclose. Dr. Borlot has nothing to disclose. Dr. Butcher has nothing to disclose. Dr. Chow has nothing to disclose. Dr. Bassett has nothing to disclose. Dr. Andrade has received personal compensation for activities with Eisiai and UCB as an advisory. Dr. Andrade has received research support from Sunovion.
Source: Neurology - Category: Neurology Authors: Tags: Epilepsy and Clinical Neurophysiology: Genetics Source Type: research