Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD

Conclusions:
In a late-middle-aged cohort, CRF attenuates the adverse influence of genetic vulnerability on CSF biomarkers. These findings support the notion that increased cardiorespiratory fitness may be beneficial to those at increased genetic risk for AD.

Source: Neurology - April 24, 2017 Category: Neurology Authors: Schultz, S. A., Boots, E. A., Darst, B. F., Zetterberg, H., Blennow, K., Edwards, D. F., Koscik, R. L., Carlsson, C. M., Gallagher, C. L., Bendlin, B. B., Asthana, S., Sager, M. A., Hogan, K. J., Hermann, B. P., Cook, D. B., Johnson, S. C., Engelman, C. D Tags: Alzheimer's disease, Risk factors in epidemiology, All Genetics ARTICLE Source Type: research