Interferon- β 1a Modulates Expression of RAGE but Not S100A12 and Nuclear Factor- & #x03BA;B in Multiple Sclerosis Patients

Conclusions: It appears that S100A12 participates in the pathogenesis of MS, and it seems that IFN- β 1a modulates immune responses in an S100A12-independent manner. Based on the reported anti-inflammatory effects of RAGE, it seems that RAGE may be considered as a mechanism by IFN-β 1a to modulate immune responses. NF-#x03BA;B is produced permanently in the human cells and is inactive in the cyt oplasm; therefore, the effects of IFN-β 1a may be related to its functions rather than expressions.Neuroimmunomodulation
Source: Neuroimmunomodulation - Category: Allergy & Immunology Source Type: research