Inhibition of pro-inflammatory enzymes by medicinal plants from the Argentinean highlands (Puna)

Conclusions Six out of the 13 species investigated showed a moderate to strong effect towards the enzyme sPLA2 (>40% inhibition at 200µg/mL) while three species presented strong activity against LOX with IC50< 250µg/mL and three were very active against hyaluronidase. Most of the crude drug extracts were able to stabilize the red blood cells membrane preventing their lysis. The compounds identified in the extracts can explain, at least in part, the activity found in the samples. The effect observed for the most active species support their traditional use as anti-inflammatory agents. However, more studies should be undertaken to disclose the potential of the Puna plants as anti-inflammatory crude drugs. Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research