Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD

Conclusions
Shifts in gut bacterial diversity and composition associated with iron treatment are pronounced in IBD participants. Despite similar clinical outcome, oral administration differentially affects bacterial phylotypes and faecal metabolites compared with IV therapy.

Trial registration number
clinicaltrial.gov (NCT01067547).

Source: Gut - April 7, 2017 Category: Gastroenterology Authors: Lee, T., Clavel, T., Smirnov, K., Schmidt, A., Lagkouvardos, I., Walker, A., Lucio, M., Michalke, B., Schmitt-Kopplin, P., Fedorak, R., Haller, D. Tags: Crohn's disease, Open access Inflammatory bowel disease Source Type: research