A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex.

CONCLUSIONS: ApoM/S1P in light HDL particles were inefficient in inhibiting tumor necrosis factor-α-induced vascular cellular adhesion molecule-1 expression in contrast to apoM/S1P in denser HDL particles. T1D patients have a higher proportion of light particles and hence more dysfunctional HDL, which could contribute to the increased cardiovascular disease risk associated with T1D. PMID: 28385702 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28385702?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - April 6, 2017 Category: Cardiology Authors: Frej C, Mendez AJ, Ruiz M, Castillo M, Hughes TA, Dahlbäck B, Goldberg RB Tags: Arterioscler Thromb Vasc Biol Source Type: research