Selective Loss of Smaller Spines in Schizophrenia.

CONCLUSIONS: These findings require a rethinking of the overpruning hypothesis, demonstrate a link between small spine loss and a schizophrenia risk gene, and should spur more in-depth investigations of the mechanisms that govern new or small spine generation and stabilization under normal conditions as well as how this process is impaired in schizophrenia. PMID: 28359200 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28359200?dopt=Abstract

Source: The American Journal of Psychiatry - March 31, 2017 Category: Psychiatry Authors: MacDonald ML, Alhassan J, Newman JT, Richard M, Gu H, Kelly RM, Sampson AR, Fish KN, Penzes P, Wills ZP, Lewis DA, Sweet RA Tags: Am J Psychiatry Source Type: research