Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds: MMV665953 {1-(3-chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea} and MMV665807 {5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide}.

CONCLUSION: MMV665953 and MMV665807 are more bactericidal against S. aureus biofilms than currently used anti-staphylococcal antibiotics and represent a valuable structural basis for further investigation in the treatment of staphylococcal biofilm-related infections.
PMID: 28327271 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - March 23, 2017 Category: Microbiology Authors: Zapotoczna M, Boksmati N, Donohue S, Bahtiar B, Boland A, Somali HA, Cox A, Humphreys H, O'Gara JP, Brennan M, O'Neill E Tags: J Med Microbiol Source Type: research