Differentiation capacity and maintenance of dental pulp stem/progenitor cells in the process of pulpal healing following tooth injuries

Conclusion Host and recipient interactions that occur with allografts disturb the maintenance of putative stem/progenitor cells, resulting in the disappearance of these cell types.
Source: Journal of Oral Biosciences - Category: Biomedical Science Source Type: research

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Bioengineers and dentists from the UCLA School of Dentistry have developed a new hydrogel that is more porous and effective in promoting tissue repair and regeneration compared to hydrogels that are currently available. Once injected in a mouse model, the new hydrogel is shown to induce migration of naturally occurring stem cells to better promote bone healing. Current experimental applications using hydrogels and stem cells introduced into the body or expensive biological agents can come with negative side effects.The  findings, published online in the journal Nature Communications, suggest that in the near future th...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
The foundation of successful strategy in thoracic transplantation is to overcome multiple barriers to donor and recipient compatibility. Once blood group barriers are surmounted, anatomic considerations become a principal guiding consideration. The available allograft may not be of similar size as the recipient's diseased organ (Figure 1). An undersized allograft is associated with an increased risk of primary graft dysfunction (PGD) in both heart1 and lung transplantation,2 making assessment of donor-recipient size match a fundamental issue.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Editorial Source Type: research
Meniscus allograft transplantation is a valuable surgical option for post-meniscectomy syndrome. For best results, the selected allograft should be as similar as possible to the original meniscus. Three-dimensional meniscus sizing could be a new approach to improve the accuracy of meniscus matching. The contralateral anatomy might therefore be a suitable reconstruction template. The purpose of this study was to compare the three-dimensional shape of the right and left menisci by bi-planar segmentation of magnetic resonance imaging (MRI) scans.
Source: The Knee - Category: Orthopaedics Authors: Source Type: research
In this study, it was aimed to compare BKV DNA measurement values performed with two different real-time polymerase chain reaction (PCR) methods and to determine BKV genotypes in renal transplant recipients. Totally, 150 clinical samples tested previously in two different laboratories (Lab-1 and Lab-2) from adult and pediatric renal transplantation patients were included in the study. Fifty plasma samples of 50 different patients from Lab-1, 50 plasma and 50 urine samples of 58 different patients from Lab-2 were included in the study. Viral nucleic acid extraction was performed with automatized systems in Lab-1 and Lab-2 (...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Long-term tolerance of islet allografts may be possible without prolonged immunosuppression, according to studies in monkeys.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Transplantation News Source Type: news
In the current issue of the Journal, dual imaging vasodilator stress echocardiography (SE) with combined assessment of regional wall motion abnormalities and coronary flow velocity reserve shows excellent feasibility and negative predictive value for excluding significant cardiac allograft vasculopathy (CAV) in patients evaluated after heart transplantation (HT) [1]. These results add further evidence to previous similar experiences showing that SE can offer several opportunities in HT setting for acute and chronic rejection surveillance and heart recruitment from marginal donors.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Authors: Pickell M, Jejurikar N, Anil U, Salata M, Davidson PA, Jazrawi LM, Strauss EJ Abstract Meniscal tears are common injuries that may result in functionally limiting pain, swelling, and mechanical symptoms. The management of meniscal pathology has evolved as surgeons' understanding of the important role the menisci play in normal knee kinematics increases. Recent emphasis on partial meniscectomy, expanding indications for meniscal repair, and the increased use of meniscal allograft transplantation have helped improve the outcomes of patients with a meniscal tear who undergo treatment. Orthopaedic surgeons sho...
Source: Instructional Course Lectures - Category: Orthopaedics Tags: Instr Course Lect Source Type: research
Contributor : Jessica ChangSeries Type : Expression profiling by arrayOrganism : Homo sapiensImproved understanding of lung transplant disease states is essential because failure rates are high, often due to chronic lung allograft dysfunction. However, histologic assessment of lung transplant transbronchial biopsies (TBBs) is difficult and often uninterpretable even with 10 pieces. All 242 single-piece TBBs produced reliable transcript measurements. Paired TBB pieces available from 12 patients showed significant similarity but also showed some sampling variance. Alveolar content, as estimated by surfactant transcript expre...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
CONCLUSIONS Non-invasive investigations of the liver microcirculation and hemoglobin oxygenation were shown to be predictive factors for EAD following liver transplantation. PMID: 31417074 [PubMed - in process]
Source: Annals of Transplantation - Category: Transplant Surgery Authors: Tags: Ann Transplant Source Type: research
Contributors : Elisabet Van Loon ; St éphane Gazut ; Saleh Yazdani ; Evelyne Lerut ; Henriette de Loor ; Maarten Coemans ; Laure-helene Noel ; Lieven Thorrez ; Leentje Van Lommel ; Frans Schuit ; Ben Sprangers ; Dirk Kuypers ; Marie Essig ; Wilfried Gwinner ; Dany Anglicheau ; Pierre Marquet ; Maarten NaesensSeries Type : Expression profiling by arrayOrganism : Homo sapiensMicroarrays were used to analyze the gene expression in peripheral blood and kidney allograft biopsies from patients with a kidney transplantation to get more insight in the molecular mechanisms underlying the different clinical phenotypes of kidn...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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