Wine Polyphenols Exert Antineoplasic Effect on Androgen Resistant PC-3 Cell Line Through the Inhibition of the Transcriptional Activity of COX-2 Promoter Mediated by NF-kβ

CONCLUSIONS: Polyphenols inhibit transcriptional activity of COX-2 promoter mediated by NF-kβ. This effect could explain, at least in part, the induction of apoptosis in vitro by these substances in castration resistant PCa.
PMID: 24836925 [PubMed - as supplied by publisher]

Source: Actas Urologicas Espanolas - May 13, 2014 Category: Urology & Nephrology Authors: Ferruelo A, de Las Heras MM, Redondo C, Ramón de Fata F, Romero I, Angulo JC Tags: Actas Urol Esp Source Type: research