Functional imaging of physiological and pathological speech production.

This article summarizes the insights from neuroimaging on physiological speech production and also on the pathomechanisms underlying Parkinson's disease and developmental stuttering. PMID: 24832012 [PubMed - as supplied by publisher]
Source: Der Nervenarzt - Category: Neurology Authors: Tags: Nervenarzt Source Type: research

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The most common age-related neurodegenerative conditions are associated with the build up of various protein aggregates, chemically altered or misfolded proteins that can form solid deposits in and around cells when in that state. These protein aggregates are characterized by the ability to spread and grow, acting as seeds for more aggregation. They include the well known amyloid-β and tau of Alzheimer's disease, the α-synuclein associated with Parkinson's disease, and so forth. In recent years researchers have been devoting ever more effort to investigations of a less well known protein aggregate, TDP-43, assoc...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Authors: Ding M, Chen Y, Luan H, Zhang X, Zhao Z, Wu Y Abstract Traumatic brain injury (TBI) affects people in all demographics, since it is associated with a variety of chronic degenerative diseases, such as Alzheimer's and Parkinson's disease. In TBI, the central nervous system elicits an immune response involving various immune cells that is necessary for healing and defending the body against pathogens, but can also cause secondary damage to the brain if the response is prolonged. In our clinical practice, it has been identified that administration of dexmedetomidine was associated with reduced production of in...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
ConclusionShifting from CV stimulation to CC stimulation may improve DBS-induced AEO. The exact mechanism underlying this improvement is unknown and further studies are needed to confirm the efficacy of CC stimulation for AEO.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Publication date: Available online 15 August 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Haitian Nan, Kai Li, Shuhua Li, Wen Su, Haibo ChenAbstractBackgroundThe Guideline for Management of Parkinson's Disease in China was published in 2006 to standardize Parkinson's disease treatment. Our objective was to compare the initial PD treatment and their accordance with the recommendations before and after the guideline publication.MethodsWe identified 136 PD patients as part of a hospital-based study in Beijing, and compared the prescriptions of dopamine agonists (DA) and levodopa (LD) as initial therapy to evaluate the...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Publication date: Available online 15 August 2019Source: Forensic Science International: GeneticsAuthor(s): Ruiyang Tao, Wenjie Qi, Chong Chen, Jingyi Zhang, Zihao Yang, Wei Song, Suhua Zhang, Chengtao LiAbstractWith the continuous development of massively parallel sequencing (MPS), increasing numbers of laboratories have utilized this method for forensic genomic analyses. When sequencing common short tandem repeats (STRs), MPS does have many advantages over the length-based genotyping method that uses traditional capillary electrophoresis (CE) technology. The Precision ID GlobalFilerTM NGS STR Panel v2 was recently releas...
Source: Forensic Science International: Genetics - Category: Forensic Medicine Source Type: research
PAUL SINHA was diagnosed with Parkinson ’s disease in May of this year. The Chase star is now using his journey with the degenerative brain condition as material for his new comedy and putting a lighter spin on the disease.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
ConclusionPD is a multifactorial disorder involving interplay of aging, genetics and environmental factors. This has implications on the development of appropriate animal models of PD which take all these factors into account. Common converging pathways likely include mitochondrial dysfunction, impaired autophagy, oxidative stress and neuroinflammation, which are associated with the accumulation and spread of misfolded α-synuclein and neurodegeneration. Understanding the mechanisms involved in the initiation and progression of PD may lead to potential therapeutic targets to prevent PD or modify its course.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
Speech disorders, including stuttering and hypophonia, have been reported in patients with Parkinson's disease (PD) after subthalamic deep brain stimulation (STN-DBS).
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
SLPs came to ASHA’s Health Care Connect conference ready to learn about dysphagia, head and neck cancer, Parkinson’s disease, concussion, delirium—and much more. Across three days of sessions, SLPs heard how their unique skills and training prepared them to work as an integral part of multidisciplinary teams. Editor’s note: This is part two of a series on tips SLPs learned at ASHA Connect 2018. Read part one for insights heard from attendees of the schools’ sessions. Ruth Snyder, an SLP and solo practitioner in Jacksonville, Florida, began her Friday morning at Vivian Sisskin’s session, ...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Academia & Research Events Health Care Private Practice Schools Slider Speech-Language Pathology dementia Dysphagia Parkinson's Speech Disorders Source Type: blogs
Stuttering is a speech disorder with disruption of verbal fluency, occasionally present in Parkinson's disease (PD). PD co-incident stuttering may either worsen or improve after Deep Brain Stimulation (DBS).
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Short communication Source Type: research
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