PodMed – Week of March 13, 2017

This week’s topics include how often women need pelvic exams, what we can learn from the oldest old, mouse allergens and asthma, and cardiometabolic death and diet. Program notes: 0 :30 Learning from the oldest old 1:30 Physical performance and cognitive function 2:30 Living longer but more frail 2:50 Pelvic exam interval 3:52 Abandoning altogether […]
Source: Johns Hopkins Medicine Weekly Health News - Category: Consumer Health News Authors: Tags: All Podcasts Allergy Alzheimer's Disease And Dementia Death and Dying Diet PodMed Reproductive Health Source Type: podcasts

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Authors: Lee G, Cummings J, Decourt B, Leverenz JB, Sabbagh MN Abstract Introduction: Dementia with Lewy bodies (DLB) is an under-researched area despite being the second most common type of degenerative dementia after Alzheimer's disease. It is an area of unmet need with no approved symptomatic or disease-modifying therapies. The pharmacological management of DLB is complex and challenging because early trials of drugs for DLB have resulted in no demonstrable efficacy. Randomized controlled trials (RCTs) in the DLB population have only recently been initiated. Understanding results from previous and current clinic...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Publication date: Available online 15 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Edward D. Chan, Michael M. Chan, Mallory M. Chan, Paul E. MarikAbstractGlucocorticoids (GC) in all its various forms and formulations are likely one of the most commonly used pharmacologic agents in medicine. Their use can be profoundly therapeutic but are also associated with a myriad of acute and chronic side effects. It is fairly well-accepted in the medical community that GC can be life-saving when used in critically ill patients with severe exacerbations of asthma and chronic obstructive pulmonary disease, HIV-associated...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 15 October 2019Source: Journal of Herbal MedicineAuthor(s): Tarun Sharma, Snehasis JanaAbstractBoswellic acids (BAs) are the important active constituents of the plant Boswellia serrata which has been widely used for the treatment of several acute and chronic inflammatory diseases. These acids have shown their very potent anti-inflammatory activities in both in vitro and in vivo animal models. Also, their anti-arthritic, anti-rheumatic, anti-diarrhoeal, anti-hyperlipidemic, anti-asthmatic, anticancer, anti-microbial, analgesic activity, hepatoprotective, and immunomodulatory activities ha...
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research
Previous functional imaging studies have identified the role of central autonomic network (CAN) in autonomic regulation during various tasks. However, its variability with respect to gender and age, particularly in the resting state, remains poorly understood. Therefore, in this study we systematically investigated gender- and age-related differences in the resting-state functional connectivity (rsFC) seeded from core regions of this network, namely posterior mid-cingulate gyrus (pMCC), left amygdala, right anterior and left posterior insula, and ventromedial prefrontal cortex (vmPFC), using a large cross-sectional adultho...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
In conclusion, compared with placebo, Brazilian propolis supplementation did not influence the risk of atopic sensitization in infants and neither did it improve nor worsen nonspecific symptoms in either mothers or their infants. PMID: 31611924 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Publication date: Available online 15 October 2019Source: Stem Cell ResearchAuthor(s): Lin Zhang, Mei Xu, Gang Liu, Rongrong Wu, Shulin Meng, Kang Xiahou, Ning Jiang, Yongxiang Zhang, Wenxia ZhouAbstractA 62-year old sporadic Alzheimer's disease (sAD) male patient with APOE3 (ε3/ε3) genotype donated his peripheral blood mononuclear cells (PBMCs). The induced pluripotent stem cell (iPSC) line was established by episomal vector system with the four factors OCT4, SOX2, C-MYC and KLF4. EB differentiation in vitro showed that iPSC line had a potential to differentiate into three germ layers. More than 90% cells ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Last month, House Speaker Nancy Pelosi unveiled aradical drug pricing plan, H.R. 3, that could jeopardize the development of innovative treatments for some of the most challenging diseases and leave U.S. patients behind. Take for example, Alzheimer ’s disease, a ruthless disease which devastates the minds of 5.7 million Americans and creates substantial burdens for families and caregivers.
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: Research and Development Economic Impact Medicare Research and Investment Source Type: news
Many of today’s most popular drugs can make you forgetful. They inhibit your brain’s chemical messengers. And this blocks your concentration, memory and ability to focus. More specifically, these drugs block the activity of a neurotransmitter in your brain called acetylcholine. Acetylcholine is directly involved in learning and memory. And blocking it is a risky business… I’ve seen confusion, memory loss, and declining mental skills in patients who take these drugs. New research confirms what I see in my own practice. One recent study found that people taking these kinds of drugs had shrunken ar...
Source: Al Sears, MD Natural Remedies - Category: Complementary Medicine Authors: Tags: Anti-Aging Source Type: news
ConclusionsMechanisms connecting depression to physical illness appear to involve alterations in the hypothalamic‐pituitary axis, unhealthy lifestyle, chronic or acute stressors including posttraumatic stress, an increase in C‐reactive protein (CRP) in men, taking antidepressant medication, and social and emotional loneliness. Clinical RelevanceA good patient–provider relationship can help to promote decreased acute or chronic stressors, increased family and social support, decreased loneliness, modification of unhealthy lifestyles such as smoking, obesity, physical inactivity, alcohol, control of CRP, and antide...
Source: Journal of Nursing Scholarship - Category: Nursing Authors: Tags: CLINICAL SCHOLARSHIP Source Type: research
ConclusionsMechanisms connecting depression to physical illness appear to involve alterations in the hypothalamic‐pituitary axis, unhealthy lifestyle, chronic or acute stressors including posttraumatic stress, an increase in C‐reactive protein (CRP) in men, taking antidepressant medication, and social and emotional loneliness. Clinical RelevanceA good patient–provider relationship can help to promote decreased acute or chronic stressors, increased family and social support, decreased loneliness, modification of unhealthy lifestyles such as smoking, obesity, physical inactivity, alcohol, control of CRP, and antide...
Source: Journal of Nursing Scholarship - Category: Nursing Authors: Tags: CLINICAL SCHOLARSHIP Source Type: research
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