Vismodegib Therapy for Basal Cell Carcinoma in an 8 ‐Year‐Old Chinese Boy with Xeroderma Pigmentosum

This article reports clearance of a nodular BCC of the nasal tip in an 8‐year‐old boy with xeroderma pigmentosum (XP). BCC can pose therapeutic challenges when located in areas that are not amenable to traditional therapies such as Mohs micrographic surgery or topical agents. Vismodegib was used at a dose of 150 mg/day to treat the boy's BCC. After 4 months of therapy, we achieved complete clinical clearance. During 21 months of follow‐up, the patient's nose remained clinically clear of tumor. Vismodegib was successfully used to treat a child with XP and nodular BCC. Our goal in using vismodegib was tumor regression while avoiding cosmetic and functional disfigurement. Vismodegib was effective in clinically clearing the tumor, and the patient has shown no signs of recurrence. Further studies are warranted.
Source: Pediatric Dermatology - Category: Dermatology Authors: Tags: Case Report Source Type: research