First-line screening tests for Cushing ’s syndrome in patients with adrenal incidentaloma: the role of urinary free cortisol measured by LC-MS/MS

ConclusionsThe 1-mg DST at its lowest threshold presented high sensitivity in identifying CS, but its low specificity encourages us to consider UFC levels, measured with LC-MS/MS, to reduce false-positive test results. High UFC levels could also be considered as markers to stratify cardiovascular risk in patients with adrenal incidentaloma.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research