JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate

Conclusions</div>HF activates the LA JAK-STAT system and enhances PDGF-signalling. JAK-STAT inhibition reduces the profibrotic effects of PDGF stimulation on canine fibroblasts <span style="font-style:italic;">in vitro</span> while attenuating <span style="font-style:italic;">in vivo</span> LA-fibrosis and remodelling in post-MI mice, suggesting that the JAK/STAT pathway contributes to LA-fibrogenesis and might be a potential target for LA-fibrosis prevention.</span>
Source: Cardiovascular Research - Category: Cardiology Source Type: research