Single nucleotide polymorphisms related to cystic fibrosis in chronic rhinositus —a pilot study

BackgroundThe clinical association between cystic fibrosis (CF) and chronic rhinosinusitis (CRS) is well known. Studies have identified several non‐CF transmembrane conductance regulator single nucleotide polymorphisms (SNPs) associated with disease severity in CF patients. We hypothesized that prevalence of these SNPs would be different between CRS patients and age/gender‐matched non‐CRS controls. MethodsThis is a targeted SNP study of 1231 CRS patients identified through a large university hospital database who were compared with 8796 age‐ and gender‐matched controls without a history of rhinitis, sinusitis, allergies, or asthma. Prevalence of 5 relevant SNPs was compared between groups, with p
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research

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CONCLUSION Infrastructural adequacy of PHCC was associated with less PCSC hospitalizations, while availability medical professional and medications were associated with higher PCSC hospitalizations.
Source: Revista de Saude Publica - Category: International Medicine & Public Health Source Type: research
Anyone have any insight on Allergy&Immunology job market, lifestyle, and salary? Have heard that field is struggling in PP due to primary care docs taking over procedures but I wonder how true this is especially in urban centers like SF/LA/NYC/Chicago/Miami?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Other Subspecialties Source Type: forums
Condition:   Asthma in Children Interventions:   Device: Pneumopipe® (European patent 12425057.2, Rome, Italy);   Other: Other assessments Sponsors:   Istituto per la Ricerca e l'Innovazione Biomedica;   Campus Bio-Medico University Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   COVID-19;   Coronavirus Infections;   Hay Fever;   Asthma;   Chronic Obstructive Pulmonary Disease;   Influenza;   Common Cold;   Respiratory Tract Infections;   Healthy Intervention:   Sponsor:   HealthMode Inc. Recruiting
Source: - Category: Research Source Type: clinical trials
Chronic rhinosinusitis with nasal polyposis (CRSwNP) represents a subset of chronic sinusitis with various causes. Some forms of the disease are driven by allergy, often in association with asthma. Refractory CRSwNP can be associated with cystic fibrosis and other clinical syndromes. More recent literature is presented regarding roles of innate immunity and superantigens. Effective treatment of CRSwNP requires careful endoscopic sinus surgery followed by an individualized treatment plan that often includes oral and topical steroids. Recidivism of polyps is common, and patients require long-term follow-up.
Source: Otolaryngologic clinics of North America - Category: ENT & OMF Authors: Source Type: research
Authors: Shah A, Panjabi C Abstract In susceptible individuals, inhalation of Aspergillus spores can affect the respiratory tract in many ways. These spores get trapped in the viscid sputum of asthmatic subjects which triggers a cascade of inflammatory reactions that can result in Aspergillus-induced asthma, allergic bronchopulmonary aspergillosis (ABPA), and allergic Aspergillus sinusitis (AAS). An immunologically mediated disease, ABPA, occurs predominantly in patients with asthma and cystic fibrosis (CF). A set of criteria, which is still evolving, is required for diagnosis. Imaging plays a compelling role in th...
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Hello all. I am a 20 year old male, and was recently tested via sweat test for CF. I received the call five days ago that I did not have CF due to the results, but I am not fully confident (as online research has led me to discover that in some, albeit very few, cases, the sweat test may produce normal results despite the patient having CF). Here's why I am not fully confident: 1) I was diagnosed with asthma at a young age--however, this asthma is so mild that it has a negligible impact on my life as of now. I need to take two puffs of my albuterol inhaler MAYBE once a week, if not less than that. I do not usually need i...
Source: Cystic Fibrosis Newly Diagnosed Forum - Category: Respiratory Medicine Authors: Tags: Newly Diagnosed Source Type: forums
Hi Everyone. Well, I had a ambry Pancreatitis Genetic panel done. Any one else, with pancritis problems, Cf etc, which know of theses mutations. G576A, (likely pathogenic) And R668C. (Variant of unknown Significance) Got as far as a CRMS Diagnose. Told neither of these are CF causing. I don't get this as I am still in limbo, The two high sweat test> 84, and 90. To make this short as I always write a book here, I do have good FVC. Low DLCO. (which I think is heart related) Chronic Asthma, Chronic Sinusitis, Allergies, Chronic Bronchitis, Failure to thrive, malnusorption disorder (most all my life) Chronic Pancritis, Oste...
Source: Cystic Fibrosis DNA and Mutations Forum - Category: Respiratory Medicine Authors: Tags: DNA and Mutations Source Type: forums
Objective This update of a 2007 guideline from the American Academy of Otolaryngology—Head and Neck Surgery Foundation provides evidence-based recommendations to manage adult rhinosinusitis, defined as symptomatic inflammation of the paranasal sinuses and nasal cavity. Changes from the prior guideline include a consumer added to the update group, evidence from 42 new systematic reviews, enhanced information on patient education and counseling, a new algorithm to clarify action statement relationships, expanded opportunities for watchful waiting (without antibiotic therapy) as initial therapy of acute bacterial rhinos...
Source: Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Authors: Tags: Guideline Source Type: research
The American Academy of Otolaryngology—Head and Neck Surgery Foundation has published a supplement to this issue featuring the updated "Clinical Practice Guideline: Adult Sinusitis" as a supplement to Otolaryngology–Head and Neck Surgery. To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements. The 14 developed recommendations address diagnostic accuracy for adult rhinosinusitis, the appropriate use of ancillary tests to confirm diagnosis and guide management (including radiography, nasal endoscopy, computed tomography, and tes...
Source: Otolaryngology - Head and Neck Surgery - Category: ENT & OMF Authors: Tags: Guideline Executive Summary Source Type: research
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