Cardio Pharm Question

Mr Green, a 54-year-old banker, had a cardiac transplant 6 months ago. His current blood pressure is 120/70 mm Hg and heart rate is 100 bpm. Which of the following drugs would have the least effect on Mr Green's heart rate? (A)Albuterol (B)Epinephrine (C)Isoproterenol (D)Norepinephrine (E)Phenylephrine Answer : E Could someone please explain why E is correct? Thank you Wouldn't you get reflex bradycardia w/ Phenylephrine?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Source Type: forums

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This article reviews current trends in the use of DT VAD, adverse events in children versus adults on VAD, and provides a framework for patient selection employing a multi-disciplinary approach including palliative care. The general approach to determining DT VAD candidacy should include: 1) a reasonable success that the patient will survive the peri- and post-operative state and 2) a high likelihood that the patient will be able to be discharged out of hospital and have adequate caregiver support. Patients with muscular dystrophy and failing Fontan physiology are examples of two pediatric populations for whom DT VAD may b...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Americans aren’t sleeping well. Roughly 80% of U.S. adults say they struggle to fall asleep at least one night a week, according to a recent Consumer Reports survey. And research has found that sleep problems are also on the rise among adolescents. While the causes of America’s sleep woes are up for debate, there’s little disagreement about America’s favorite remedy: Melatonin, by far the country’s most-used sleep aid. What is Melatonin? Melatonin is a hormone that plants and animals, including humans, produce naturally. The melatonin sold in over-the-counter pills is synthetic, but chemically...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized anti-oxidants drug safety inflammation medicine melatonin Source Type: news
CONCLUSIONS: ASC sheets prevented cardiac dysfunctions and remodeling after MI in a rat model via VEGF secretion. Inhibition of VEGF effects by carvedilol abolished their beneficial effects. PMID: 31527337 [PubMed - as supplied by publisher]
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research
ConclusionHTxRs are characterized by elevated blood pressures and total peripheral resistance at supine rest as well as attenuated blood pressures and total peripheral resistance responses during orthostatic challenge, possibly caused by low-pressure cardiopulmonary baroreceptor denervation. In addition, HTxRs show attenuated cardiac output response during isometric exercise due to efferent sympathetic denervation. These physiological limitations might have negative functional consequences.
Source: European Journal of Applied Physiology - Category: Physiology Source Type: research
Authors: Palladino A, Papa AA, Morra S, Russo V, Ergoli M, Rago A, Orsini C, Nigro G, Politano L Abstract Cardiomyopathy associated with dystrophinopathies - Duchenne muscular Dystrophy (DMD), Becker muscular dystrophy (BMD), X-linked dilated cardiomyopathy (XL-CM) and cardiomyopathy of Duchenne/Becker (DMD/BMD carriers - is an almost constant manifestation of these neuromuscular disorders and contribute significantly to their morbidity and mortality. Dystrophinopathic cardiomyopathy is the result of the dystrophin protein deficiency at the myocardium level, parallel to that occurring at the skeletal muscle level....
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
DISCUSSION: The clinical, genetic, and muscle biopsy findings suggest that both mutations are pathogenic. The EXT2 mutation was most likely responsible for the multiple exostoses phenotype in mother and son, whereas the myopathy was probably caused by a combined effect of the LMNA and EXT2 mutations.
. PMID: 31296281 [PubMed - as supplied by publisher]
Source: Clinical Neuropathology - Category: Pathology Authors: Tags: Clin Neuropathol Source Type: research
In this study, we determine whether transient reintroduction of embryonic stem cell cycle miR-294 promotes cardiomyocyte cell cycle reentry enhancing cardiac repair after myocardial injury. A doxycycline-inducible AAV9-miR-294 vector was delivered to mice for activating miR-294 in myocytes for 14 days continuously after myocardial infarction. miR-294-treated mice significantly improved left ventricular functions together with decreased infarct size and apoptosis 8 weeks after MI. Myocyte cell cycle reentry increased in miR-294 hearts parallel to increased small myocyte number in the heart. Isolated adult myocytes from miR-...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionSGB increased cSNRT without changing heart rate. CSD was more beneficial for patients with mild ‐to‐moderate heart failure and faster VA.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - Category: Cardiology Authors: Tags: ORIGINAL ‐ CLINICAL Source Type: research
Publication date: Available online 4 June 2019Source: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)Author(s): I. Casáns-Tormo, A. Jiménez-Heffernan, V. Pubul-Núñez, R. Ruano-PérezAbstractImaging of cardiac sympathetic innervation is only possible by nuclear cardiology techniques and its assessment is key in the evaluation of and decision-making for patients with cardiac sympathetic impairment. This review includes the basis of cardiac sympathetic scintigraphy with 123I-meta-iodobenzylguanidine (123I-MIBG), recommended protocols, patient preparation, imag...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
304Objectives: Pure autonomic failure (PAF, formerly called idiopathic orthostatic hypotension) is a rare Lewy body disease that features neurogenic orthostatic hypotension from generalized deficiency of the sympathetic neurotransmitter norepinephrine. Cardiac sympathetic neuroimaging by 18F-dopamine (18F-DA) positron emission tomographic (PET) scanning has consistently shown severely decreased myocardial 18F-DA-derived radioactivity in PAF, indicating cardiac sympathetic denervation. Since norepinephrine is synthesized in vesicles, decreased vesicular uptake might also contribute to sympathetic neurocirculatory failure in...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Cardiovascular Clinical Science: Improving Prognostication from Cardiac Nuclear Imaging Source Type: research
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