Impact of celecoxib on inflammation during cancer surgery: a randomized clinical trial

DiscussionStandard dosing of the cyclooxygenase-2 inhibitor celecoxib slightly reduced perioperative cyclooxygenase activity during cancer surgery. Given cyclooxygenase ’s role in cancer pathways, we recommend dose-finding studies be undertaken before prospective clinical trials are conducted testing the currently unsubstantiated hypothesis that perioperative anti-inflammatory administration improves long-term cancer outcomes. This trial was registered at: Austra lian New Zealand Clinical Trial Registry: ACTRN12615000041550;www.anzctr.org.au
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research