Down-regulation of proangiogenic microRNA-126 and microRNA-132 are early modulators of diabetic cardiac microangiopathy

Conclusions
These novel findings demonstrate that the down-regulation of angiomiRs is a major underlying mechanism for the development of microangiopathy in diabetic hearts. Therefore, therapeutic restoration of angiomiRs could become a potential approach to combat the cardiovascular complications of diabetes.

Source: Cardiovascular Research - January 8, 2017 Category: Cardiology Authors: Rawal, S., Munasinghe, P. E., Shindikar, A., Paulin, J., Cameron, V., Manning, P., Williams, M. J. A., Jones, G. T., Bunton, R., Galvin, I., Katare, R. Tags: Vascular biology Source Type: research