STAT4-associated natural killer cell tolerance following liver transplantation

Conclusions
LT is associated with transcriptional and functional changes in NK cells, resulting in reduced activation. NK cell tolerance occurs upstream of major histocompatibility complex (MHC) class I mediated education, and is associated with deficient STAT4 phosphorylation. STAT4 therefore represents a potential therapeutic target to induce NK cell tolerance in liver disease.

Source: Gut - January 5, 2017 Category: Gastroenterology Authors: Jamil, K. M., Hydes, T. J., Cheent, K. S., Cassidy, S. A., Traherne, J. A., Jayaraman, J., Trowsdale, J., Alexander, G. J., Little, A.-M., McFarlane, H., Heneghan, M. A., Purbhoo, M. A., Khakoo, S. I. Tags: Open access Hepatology Source Type: research