Ocular Nerve Growth Factor Administration Modulates Brain-derived Neurotrophic Factor Signaling in Prefrontal Cortex of Healthy and Diabetic Rats.

CONCLUSION: The present data confirm the capacity of ed-NGF treatment to affect brain neurons and lead to brain damage recovery by activating protective and remodeling pathways triggered by BDNF. We suggest that the ed-NGF-induced changes in BDNF signaling might influence the manifestation of depressive phenotype in diabetic rats. PMID: 28044424 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28044424?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - January 2, 2017 Category: Neuroscience Authors: Rosso P, De Nicolò S, Carito V, Fiore M, Iannitelli A, Moreno S, Tirassa P Tags: CNS Neurosci Ther Source Type: research