“Do you take your drug?” Development of an UHPLC-MS/MS method to quantify antihypertensive drugs in human plasma, for the assessment of therapeutic adherence in patients with “resistant” hypertension

Introduction: Nowadays hypertension is becoming increasingly regarded since its prevalence rises with the progressive aging of global population. In a little fraction of hypertensive patients (15-30%) the administration of one or two drugs is not enough to achieve adequate blood pressure values. These cases are defined as “resistant hypertension” (RH) and require at least three antihypertensive drugs. Not-pharmacological treatment, in these cases, consists in invasive surgery (e.g. renal denervation).

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - December 31, 2016 Category: Nutrition Authors: V. Avataneo, A. De Nicol ò, G. Bonifacio, F. Rabbia, E. Perlo, E. Berra, C. Fulcheri, P. Mulatero, F. Veglio, G. Di Perri, A. D'Avolio Source Type: research