Impaired fatty acid synthesis affects immune cells activation: Focus on sterol regulatory element binding factor-1c on T lymphocytes

Background: Intracellular metabolism has recently been recognized as a key determinant of immune cells differentiation and activation and animal models lacking crucial genes of lipid metabolism are currently used to unraveil their impact on immune responses. Therapeutic targeting of metabolic checkpoint is a new challenge for the treatment of immunometabolic diseases. SREBP1c is one of the three isoforms of the sterol regulatory element-binding proteins, involved in the regulation of fatty acid synthesis.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research