Common antioxidant may guard against liver disease

A common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD) in the offspring of obese mice.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSIONS: The immunohistochemical expression of TGF-β1 may be complementary to routine methods of liver fibrosis evaluation. PMID: 31187872 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
This article reviews studies of the target mechanisms of herbal treatments for insulin resistance.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, these results provided new and robust evidence for revealing the hepatoxicity of BDE-47 under obese condition and illustrated the underlying mechanism of BDE-47 induced liver fibrosis.Graphical abstract
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
The objective was to investigate risk factors associated with hepatic fibrosis in patients with type 2 diabetes and NAFLD to provide a basis for the prevention and treatment.MethodsLiver stiffness measurements (LSM) expressed in kilopascals (kPa) and controlled attenuation parameter (CAP) expressed in dB/m were diagnosed by transient elastography. Hepatic steatosis and significant fibrosis were defined as having a CAP score  ≥ 260 dB/m and an LSM score ≥ 8 kPa, respectively. Associations between fibrosis categories with anthropometric and metabolic variables were determined; then...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Conclusions: Asymptomatic hyperuricemia patients with class II obesity and NAFLD had increased risk of DCS. Determining the presence of crystal deposition, such as DCS, among patients with asymptomatic hyperuricemia might help determine whether early pharmacologic intervention is needed, especially with severe obesity or NAFLD. PMID: 31181878 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
Publication date: Available online 10 June 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Emilio Molina-Molina, Marcin Krawczyk, Ewa Stachowska, Frank Lammert, Piero PortincasaSummaryNon-alcoholic fatty liver disease (NAFLD) parallels comorbidities such as metabolic syndrome, dyslipidaemia or diabetes. Although NAFLD is very prevalent in overweight-obese individuals (i.e. body mass index ≥ 25 kg/m2), recent studies point to the presence of NAFLD in non-obese individuals, for both the Asian (
Source: Clinics and Research in Hepatology and Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: May–June 2019Source: Obesity Research &Clinical Practice, Volume 13, Issue 3Author(s): Ramy H. Bishay, Dhanya Sanjeev, Gideon Meyerowitz-Katz, Golo Ahlenstiel
Source: Obesity Research and Clinical Practice - Category: Eating Disorders & Weight Management Source Type: research
ConclusionsChildren with obesity andPNPLA3 MM genotype show lower eGFR levels compared with other genotypes, with a major effect of this polymorphism in the presence of NAFLD.
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Fibrosis affects prognoses for patients with nonalcoholic fatty liver disease (NAFLD). Several non-invasive scoring systems have aimed to identify patients at risk for advanced fibrosis, but inconclusive results and variations in features of patients (diabetes, obesity and older age) reduce their diagnostic accuracy. We sought to develop a scoring system based on serum markers to identify patients with NAFLD at risk for advanced fibrosis.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
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