Common antioxidant may guard against liver disease
A common antioxidant found in human breast milk and foods like kiwi fruit can protect against nonalcoholic fatty liver disease (NAFLD) in the offspring of obese mice.
CONCLUSIONS: The immunohistochemical expression of TGF-β1 may be complementary to routine methods of liver fibrosis evaluation. PMID: 31187872 [PubMed - as supplied by publisher]
This article reviews studies of the target mechanisms of herbal treatments for insulin resistance.
In conclusion, these results provided new and robust evidence for revealing the hepatoxicity of BDE-47 under obese condition and illustrated the underlying mechanism of BDE-47 induced liver fibrosis.Graphical abstract
The objective was to investigate risk factors associated with hepatic fibrosis in patients with type 2 diabetes and NAFLD to provide a basis for the prevention and treatment.MethodsLiver stiffness measurements (LSM) expressed in kilopascals (kPa) and controlled attenuation parameter (CAP) expressed in dB/m were diagnosed by transient elastography. Hepatic steatosis and significant fibrosis were defined as having a CAP score ≥ 260 dB/m and an LSM score ≥ 8 kPa, respectively. Associations between fibrosis categories with anthropometric and metabolic variables were determined; then...
Conclusions: Asymptomatic hyperuricemia patients with class II obesity and NAFLD had increased risk of DCS. Determining the presence of crystal deposition, such as DCS, among patients with asymptomatic hyperuricemia might help determine whether early pharmacologic intervention is needed, especially with severe obesity or NAFLD. PMID: 31181878 [PubMed - as supplied by publisher]
Publication date: Available online 10 June 2019Source: Clinics and Research in Hepatology and GastroenterologyAuthor(s): Emilio Molina-Molina, Marcin Krawczyk, Ewa Stachowska, Frank Lammert, Piero PortincasaSummaryNon-alcoholic fatty liver disease (NAFLD) parallels comorbidities such as metabolic syndrome, dyslipidaemia or diabetes. Although NAFLD is very prevalent in overweight-obese individuals (i.e. body mass index ≥ 25 kg/m2), recent studies point to the presence of NAFLD in non-obese individuals, for both the Asian (
Publication date: May–June 2019Source: Obesity Research &Clinical Practice, Volume 13, Issue 3Author(s): Ramy H. Bishay, Dhanya Sanjeev, Gideon Meyerowitz-Katz, Golo Ahlenstiel
ConclusionsChildren with obesity andPNPLA3 MM genotype show lower eGFR levels compared with other genotypes, with a major effect of this polymorphism in the presence of NAFLD.
Fibrosis affects prognoses for patients with nonalcoholic fatty liver disease (NAFLD). Several non-invasive scoring systems have aimed to identify patients at risk for advanced fibrosis, but inconclusive results and variations in features of patients (diabetes, obesity and older age) reduce their diagnostic accuracy. We sought to develop a scoring system based on serum markers to identify patients with NAFLD at risk for advanced fibrosis.