Fractures in spina bifida from childhood to young adulthood

ConclusionsThe risk of fracture is lower in adults compared with children with spina bifida. The predominant childhood fracture affects the distal femur, and immobility is the most significant risk factor for fracture. Clinical factors contributing to fracture risk need to be elucidated to enable selection of patients who require investigation and treatment of osteoporosis.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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Publication date: Available online 21 February 2020Source: Meta GeneAuthor(s): Zainab Nizar Jawad, Weaam AwadAbstractBackgroundSeveral genetic polymorphisms have been supposed to participate in urolithiasis progression. We investigated the association of the urokinase gene 3’-UTR and vitamin D receptor (VDR) polymorphisms with urolithiasis in an Iraqi population.MethodsTotally, 104 first kidney stone formers (63 males and 41 females), 100 recurrent stone formers (56 males and 44 females) and 127 healthy subjects (71 males and 56 females) were enrolled. The DNA was extracted from the peripheral blood; next the urokina...
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
ConclusionThis study indicates that an aqueous leaf extract of Boldoa purpurascens may be effective in the prevention of urinary stone formation, and substantiates the traditional claim.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Retrograde Intra Renal Surgery (RIRS) versus Percutaneous Nephrolithotomy (PCNL) for renal stones>2cm. A systematic review and meta-analysis. Minerva Urol Nefrol. 2020 Feb 19;: Authors: Barone B, Crocetto F, Vitale R, Di Domenico D, Caputo V, Romano F, De Luca L, Bada M, Imbimbo C, Prezioso D Abstract BACKGROUND: The recent advances in technology and miniaturization of endoscopic devices have permitted the use of RIRS to treat large and complicated kidney stones as first line therapy in alternative to PCNL. OBJECTIVE: Systematically review the efficacy and safety of RIRS for large renal stones o...
Source: Minerva Urologica e Nefrologica - Category: Urology & Nephrology Tags: Minerva Urol Nefrol Source Type: research
This study aimed to investigate the renal protective effect of atorvastatin (ATV) on the kidney inflammation induced by calcium oxalate (CaOx) crystals. A cell model of cell ‐crystal interactions and a rat model of CaOx kidney stone were established. The expressions of TLR4, NF‐κB, NLRP3, and cleaved caspase‐1 in cells and rat kidney tissues were detected using Western blot, immunohistochemical, and/or immunofluorescence. The concentrations of malondialdehyde (MD A), superoxide dismutase (SOD), reactive oxygen species (ROS) in cells, and lactic acid dehydrogenase (LDH) in the culture medium were measured. The s...
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research
Introduction: Nephrolithiasis (NL) is a systemic and multifactorial disorder showing high prevalence and incidence in industrialized countries. The hyposodic diet is the cornerstone of NL primary and secondary prevention. The aim of this case-control study was to estimate the usual consumption of nutritional sources of salt in recurrent stone formers (RSF), treated with Extracorporeal Shock Wave Lithotripsy (ESWL), and in healthy controls without NL (C).
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Introduction: Nephrolithiasis (NL) is a systemic multifactorial disorder characterized by high recurrence rate if not properly focused and treated. Adherence to the Mediterranean diet significantly reduces the NL recurrence rate.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
AbstractSummaryWe found that the MRI T2* value is moderately negatively correlated with the bone mineral density assessed with quantitative computed tomography in evaluating osteoporosis in postmenopausal women and may have some potential in assessing severity of lumbar osteoporosis for scientific research.PurposeTo investigate the T2* quantitative measurement in magnetic resonance imaging (MRI) and its correlation with the bone mineral density (BMD) values evaluated with quantitative computed tomography (QCT) in women with postmenopausal lumbar vertebrae osteoporosis.Materials and methodsEighty-seven postmenopausal women ...
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
ConclusionOur simulations indicate that up to 50% reduction in radiation dose through sparse sampling can be used for FE-based prediction of femoral failure load. Sparse-sampled MDCT may allow fracture risk prediction and treatment monitoring in osteoporosis with less radiation exposure in the future.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
AbstractBackgroundOsteoporosis is the most common condition contributing to 95% of fractures in older patients hospitalized for fracture treatment. Despite the significant impact of fragility fractures on patient morbidity and mortality, efforts in optimizing osteoporotic treatment and prevention remain inadequate. In contrast, in patients with limited life expectancy, withholding specific osteoporosis drug treatment appears reasonable. The threshold between under- and overtreatment is still unclear.MethodsIn 2016, we implemented a fracture liaison service (FLS) for 18  months to improve the quality of osteoporosis ca...
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
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