Different doses of dexmedetomidine reduce plasma cytokine production, brain oxidative injury, PARP and caspase expression levels but increase liver oxidative toxicity in cerebral ischemia-induced rats.

In conclusion, DEX induced protective effects against cerebral ischemia-induced brain and erythrocyte oxidative injuries through regulation of the antioxidant level and cytokine production. However, both doses of DEX induced oxidative toxicity and apoptotic effects in the rats' livers. PMID: 28007581 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28007581?dopt=Abstract

Source: Brain Research Bulletin - December 18, 2016 Category: Neurology Authors: Akpınar O, Nazıroğlu M, Akpınar H Tags: Brain Res Bull Source Type: research