Short- and long-term effects of oral vancomycin on the human intestinal microbiota

Conclusions Oral vancomycin induces drastic and consistent changes in the human intestinal microbiota. Upon vancomycin cessation, the microbiota recovery rate varied considerably among subjects, which could influence, as validated in mice, the level of susceptibility to pathogen intestinal colonization. Our results demonstrate the negative long-term effects of vancomycin, which should be considered as a fundamental aspect of the cost–benefit equation for antibiotic prescription.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Authors: Tags: Original research Source Type: research