B-cell populations discriminate between pediatric- and adult-onset multiple sclerosis

Conclusions: We demonstrate distinct changes in intrathecal B-cell homeostasis in patients with pedMS during active disease, which differ from those in adults by an expansion of plasmablasts in blood and CSF and similarly occur in prototypic autoantibody-driven autoimmune disorders. This emphasizes the particular importance of activated B-lymphocyte subsets for disease progression in the earliest clinical stages of MS.

http://nn.neurology.org/cgi/content/short/4/1/e309?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - December 14, 2016 Category: Neurology Authors: Schwarz, A., Balint, B., Korporal-Kuhnke, M., Jarius, S., von Engelhardt, K., Fürwentsches, A., Bussmann, C., Ebinger, F., Wildemann, B., Haas, J. Tags: All Pediatric, Cerebrospinal Fluid, Multiple sclerosis Article Source Type: research