Effect of Redox-Modifying Agents on the Activity of Channelrhodopsin-2.

CONCLUSION: Taken together, these data suggest that redox modification of ChR2 plays an important role in its sensitivity to the light stimulation. Our findings not only help for a better understanding of how ChR2 may behave in physiological/pathological conditions where changes in redox state are common, but also provide a new direction for further optimization of this important opsin. PMID: 27917616 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/27917616?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - December 3, 2016 Category: Neuroscience Authors: Wu BM, Leng TD, Inoue K, Li J, Xiong ZG Tags: CNS Neurosci Ther Source Type: research