Cognitive adverse effects and brain deterioration associated with use of anticholinergic activity medicines in older adults

This study examined whether medicines with anticholinergic activity alter brain glucose metabolism, and the impact this has on brain structure, function and cognitive decline. Methods This retrospective cohort study involved 402 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) centre and 49 participants from the Indiana Memory and Aging Study (IMAS). Data on cognitive and neuroimaging findings...
Source: Evidence-Based Medicine - Category: Internal Medicine Authors: Tags: Geriatric medicine, Epidemiologic studies, Dementia, Drugs: CNS (not psychiatric), Sleep disorders (neurology), Stroke, Memory disorders (psychiatry), Psychiatry of old age, Sleep disorders, Sleep disorders (respiratory medicine) Aetiology/Harm Source Type: research