APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Centers (Collaborative U01)
Funding Opportunity RFA-DK-16-025 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites cooperative agreement applications to establish a multi-center, multi-disciplinary group of investigators to be known as the APOL1 Long-term Kidney Transplantation Outcomes Research Network (APOLLO). This FOA invites applications for the APOLLO Network Clinical Centers (CCs) and runs in parallel with a separate FOA that invites applications for the APOLLO Network Scientific Data Research Center (SDRC) (RFA-DK-16-024). The APOLLO Network will design and conduct studies of a prospective longitudinal cohort to determine the impact of APOL1 genetic variants as susceptibility factors in US kidney transplant recipients who received kidneys from African American donors. In addition, the consortium will follow the course of African American kidney donors. Primary outcomes are the rate of change of kidney function in recipients, and rates of acute rejection of the kidney transplant, graft failure, and return to maintenance dialysis rates in the recipients. Outcomes, including vital and renal functional status, in donors will be assessed to the greatest extent possible.